Colchicine and Macrolides: How Drug Interactions Cause Toxicity Through P-gp and CYP3A4 Inhibition
Colchicine can be deadly when taken with certain antibiotics like clarithromycin due to dangerous interactions with CYP3A4 and P-gp enzymes. Learn why azithromycin is safe, what to do if you're at risk, and how to avoid life-threatening toxicity.